Venetica takes place in an alternate 16th century. Scarlet is the daughter of Death, though she isn't initially aware of her connection with the Grim Reaper. However, Death doesn't have a chance to alert her of her connection, because his powers and his strength have been sapped by a cult of necromancers that are trying to use his power to conquer the world. As Death's daughter, Scarlet has his same abilities, although they haven't been awakened yet. But what Scarlet does discover is that she's being hunted by the same necromancers, and she'll have to learn how to train and use her powers to defeat this threat.