Travis Bruno of Capsule Computers writes:
"Usually once a developer finds their flagship franchise they rarely deviate from that course. For Nippon Ichi Software this couldn’t be further from the truth however as the developer, who may primarily be known for their Disgaea series, has been constantly experimenting with new and different titles throughout the years. These can range from different styles of RPGs, horror games, and more as the company constantly keeps players wondering what they will be working on next. Well this time around we have Poison Control, a third-person shooter that once again steps outside the box for the company and now that it has been brought to the West, was it a worthwhile experiment?"