The Indie Game Website writes: "The Coma 2: Vicious Sisters is a side-scrolling horror with a big heart. You play Mina, a walking stereotype, who is cast into the shadowy, waxy realm of ‘The Coma’ during a normal evening at her school. "
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XBA says: More than a simple sequel, The Coma 2: Vicious Sisters improves nearly every aspect.
Games Asylum: "As time passes, I’ve fallen away from ‘big boom-boom AAA titles’ and fallen in line with gentle indies – games where you grow crops or build little towns and spend your days fishing. If you’re a fan of having your heart relocate into your mouth while you play a twisted game of cat and mouse through a nightmarish world, have a blast of The Coma 2: Vicious Sisters."