On Depression Quest

"A missed day at work becomes a full blown anxiety attack. A few stilted social functions cause you and your girlfriend to break up. Depression in the game, as in reality, destroys everything in your life except itself and as much as you want to change it, some errant thought or crippling neurosis will always prevent you from being proactive. This is why some of the choices in Depression Quest are blocked out.

"At the end of a week at work, some friends might call and ask you to come out drinking. You can see the option to go join them – it's listed at the bottom of the game screen along with all the others – but it's scrawled through with a red line. You just can't do it. Depression is an illness like the flu. You can't just will yourself to get better, to buck up and go out. Your mind makes it impossible. So does Depression Quest."