You might remember Pier Solar, the upcoming RPG that is being developed specifically for the Megadrive in celebration of the console's 20th anniversary, and is pinned for a release sometime in 2009.
If you're worried about not being able to play this game because you don't actually own a Megadrive, don't worry, Water Melon Development has told CVG that once development has finished on the Megadrive version they might start thinking about giving Xbox 360 owners a chance by releasing a remake or re-release on the Xbox Live Arcade.