indiePub has published an interview with independent game developer Zach Barth who created the game SpaceChem. Barth also created Infiminer which was the inspiration for Minecraft.
From the article:
"Barth's most recently released game is SpaceChem, a puzzle game where, as a Reactor Engineer, you create elaborate factories to transform raw materials into various valuable and useful chemical products. To do this you design a routine with various paths and actions that move elements into the proper configurations to form specific molecular formations. It's loosely based on chemical engineering and each puzzle has seemingly limitless solutions."