Diablo 3 - First Thoughts - Part 3 (

(From the Article) It seems to be the case that Diablo III will have a greater focus on empowering your weapons to the previous games in the series – perhaps with most weapons being fairly standard until you choose to specialise them with a particular rune.

This may mean it is essential to whack a “Rune of Lethality” into your favourite weapon to make it effective at higher difficulty, or by using the enhanced weapon crafting system.

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