GameSpot writes: "Despicable Me: Minion Mayhem has a bit of an identity crisis. The Nintendo DS adaptation of the whimsical, animated blockbuster movie is a cleverly designed puzzle game in which you usher supervillain Gru's helpful servants through a series of treacherous obstacles. Unfortunately, the process of actually completing these devious levels may be far beyond the reach of its target audience. The challenge quickly ramps up once the fundamentals are established early on, and most of the game comprises tricky trial-and-error tests that can be maddening to finish if don't have a lot of patience. The careful planning and perfect timing needed to pass levels is compromised by the touchy controls, which don't always respond with pinpoint precision."
GameShark: As kids, most of us dreamed of ruling the world at the head of a mindless minion army (in fact, some of us are still dreaming of it) and puzzle game Despicable Me: Minion Mayhem—based on the animated film of the same name—makes that dream a reality.
GFB: "Despicable Me is currently in theaters and making a fortune off families eager to see a heartwarming and funny movie about a big bad guy who has a change of heart. Playing second fiddle in the movie to Steve Carell’s character in the movie are the loveable minions who seem to steal the show. Unlike the home console versions of Despicable Me by D3Publisher, the Nintendo DS makes the minions the stars of the show in the subtitled “Minions Mayhem”. Surprisingly there’s not a lot of mayhem taking place though; but that doesn’t mean the minions aren’t fun."
CheatCC says, "Despicable Me: Minion Mayhem is a despicable film tie-in in which you play as Professor Gru (sort-of) in his attempt to cause mayhem with his legion of buffoonish, mindless minions. It is a puzzle game in which you control various mechanisms lying around each stage (elevators, drawbridges, springboards, etc.) in such a way that your minions, who are not directly under your control, can safely achieve their goals. Playing Despicable Me is a bottom-of-the-barrel experience and has been one of the lowlights of my life as a career gamer."