The Resident Evil franchise is full of scary, monstrous things to fight, some of which have been truly terrifying women who change shape.
How about Alex Wesker from Revelations 2? Although she's part of this "Wesker's family" thing Capcom started with Jake in RE6, which I don't like, I think she was an interesting villain.
Lady Dimitrescu—heiress of the Dimitrescu family, mistress of Castle Dimitrescu, and starring villain of Resident Evil Village—is 9'6, including her hat and high heels. For comparison's sake: the tallest man to ever live, Robert Wadlow, was 8'11.
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