Hideo Kojima's Metal Gear Solid 4: Guns of the Patriots uses Shadow Moses in Twin Suns to remind you that you can't go home again. Mostly.
An article looking at the symbolic meaning behind the cigarettes in Metal Gear Solid 4: Guns of the Patriots.
Game creator Hideo Kojima is and probably will always be best-known for his creation and stewardship of the Metal Gear series at Konami, which since his departure has been more-or-less on permanent hiatus (don't mention Survive). In his almost three decades these games evolved to the point where they predicted certain problems of the information age (MGS 2), took aim at contemporary topics like Guantanamo Bay (MGS: Ground Zeroes), and ended on a profound sense of sadness about our species' inability to break the cycles of global conflict (MGS V).
It's not clear what sparked this reflection, but Kojima's been thinking about Metal Gear Solid 4, an entry that was (and unfortunately still remains) a PlayStation 3 exclusive. In that entry the player controls an aged Solid Snake in the year 2014, caught up in a civil war being fought between Private Military Companies (PMCs).