Right now Resident Evil 2's Mr. X is the hottest villain on the block, with his hat and his memes and his physique that makes The Rock feel inadequate. These are the other greatest foes in gaming that have filled players with dread.
Sigrun? Father Gascoin? Argus? Chainsaw Zombie?
Father G was a pain for sure.
Ganondorf, sephiroth, bowser, mother brain, master hand, master xehenort/ansem/xemnas. Sephiroth is probably my biggest nemesis lol. Square loves to have him as a boss in many spinoffs and collabs even though he should only be from only one title and I love it.
Soul of Cinder, The Nameless King, Ornstein and Smough (solo walkthrough).
Orphan of Kos, Ludwig, and Aldrich
I had a hard time with the Raven King and Vergil.
Kirin from Monster Hunter. F*** your small hitboxes >:( Also can't fight Kirin with randos. They all just get carted.
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