The gameplay itself is largely intact from the original Resistance. There are a few things however that felt downgraded – at least from what the demo gives the impression of so far. The Chimera themselves seem to play more like the Human characters now. The Human side basically has the same benefits as the Chimera. All characters are able to use one of several special Chimera abilities called "Berserk."
Berserk powers are different depending on which side you're on, but you are able to choose your weapon load-out and powers from the get-go. Berserk powers include things like invisibility (while not firing), increased health recovery, more ammo dropped and the like. A Chimera player starts out with one hedgehog grenade this time as well. While this evens the playing field, it feels like it sort of goes against what the first Resistance tried to accomplish.