Pocket Gamer writes: "When Earth gets bombarded by an extraterrestrial virus, instinct dictates you whip out a DS and start tapping the infection out. But of course.
Puchi Puchi Virus, the first Nintendo DS title from publisher NIS America, combines peculiar characters with addictive puzzle gameplay for a uniquely entertaining experience. It's a little tough, but sharp as a syringe nonetheless.
As the story goes, the arrival of the Puchi virus from outer space incites Dr Kevin Longfellow into action. The young doctor, with the help of his nurse Honeydew, works to find a cure to save people being transformed into bizarre creatures."