GameVisions writes: "Despite the varying difficulty of the game and other minor issues, Prototype is simply brilliantly unique, in a time when most games are war-shooter rehashes that felt stale before they were even released, or fantasy worlds that feel distant from reality and insist on confining you to a narrow path, Prototype brings you into the gritty world of Manhattan Island in the middle of a zombie plague, with a reasonable plot and mostly believable rules of engagement, and then upsets the balance by making you incredibly powerful and redefining the entire way you think of a war-torn cityscape."
