Lucas Thomas of IGN writes:
"It's just a casual, accurate, accessible virtualization of real hamster ownership, with a slow overall pace. It should provide a relaxing solution to virtual pet fans looking for a new experience on the DS. The negative to level against it is that it isn't much of a sequel, as it doesn't share much of anything in common with the first Hamsterz Life game beyond its branding and the fact that it's also focused on hamsters – this is because Petz: Hamsterz 2 is an Americanized port of a Japanese hamster game, one that was developed by a different team and different company than those who originally did Hamsterz Life 1. So if you're a fan of the first game, be aware that you might be disappointed by what you'll find here. But if you haven't played the first one and that issue doesn't concern you, give Petz: Hamsterz 2 a look. It might have a sequel's numeral on the end of its name, but it's really a solid standalone game."