Females in gaming have been making a great name for themselves over the past few years. Instead of games doing the classic cliché, damsel in distress sort of thing, it has been more likely that the female will take the role as a strong sidekick or even main protagonist rather than the normal weak hostage cliché. The gaming industry is surrounded by the toughest of though female characters and the number of these lethal ladies just keeps growing. Over the past few years players have witnessed women being as beautiful as they are daring, as darling as they are deadly and as true as they are talented. So which 5 deadly beauties are the most dangerous of them all?
eh anyway i'd say Bayonetta, Kaine and Shinobu
From this gen, the most dangerous woman I know of in gaming would be Bayonetta. I don't think I need to explain why, but who on this list would last more than a blink of an eye against her? The only person I can think of from this gen who could beat her- given certain conditions- would be Noel Vermilion.
Last gen would have been KOS-MOS. I can't say EXACTLY why without spoiling storyline- which I'm above doing- but she's the most powerful female I can think of from ANY gen who isn't an antagonist... aside from Shion, maybe.
Outside of these four, I can't really think of anyone else I'd consider truly dangerous. The ladies on the list are certainly capable, but they're not in a realm where defending against or defeating them is pointless to hope for.