A new trailer and a bunch of new information, screenshots and gameplay experiences are up on gameplayer - the site was taken through part of the gameplay by two representatives from Radical Entertainment
"On face value Alex looks like a regular twenty something New Yorker, but hiding in the darkest of shadows of that trendy hoody is wondrous power. Alex can run up the sides of buildings, leap high into the air to grab passing helicopters, pick up tanks and hurl them at enemies or leap around in the face of danger like Parkour's messiah. But this is only the tip of the iceberg. PROTOTYPE is Crackdown on crack and Alex is no superhero; he is a supermonster."
NOTE: This has been reported for using capitals in the header. I have changed it to keep everyone happy, but should note the official name is PROTOTYPE, not Prototype.