Yesterday opens pretty grimly. Homeless people are being murdered in the most heinous ways, usually found charred after being burnt alive, with no clear motive. While the police simply don’t care and are too busy to investigate the deaths of nameless vagrants, charity worker Henry White and his best buddy, Cooper, are the first to take it upon themselves to find out just what is going on.
Fast forward a few years, and at the centre of all this is amnesiac John Yesterday, an unremarkable man with a remarkable scar on his right hand. He remembers nothing but the fact that he tried to take his own life while helping an older and richer Henry with his investigations. Following his recovery, he attempts to pick up right where he left off.