Kate Cox, Kotaku- "If you died tomorrow, if some kind of disaster struck and removed you entirely from the world, would the choices you'd made with your life to date matter?
Would it matter what you had accomplished? Who you had loved? If you had saved another's life? Would your life's work have meaning? Would there not be at least a single day in the course of your years that managed to have repercussions beyond the limits of your own knowledge and time?
I know very, very few people who would say, "no, none of it matters." It's a nihilistic and bleak point of view to maintain, that the inevitability of the final conclusion — for indeed, we are all mortal — overrides the importance of what one does along the journey. To be human is inevitably to face death. The moments we live for, before the end comes, are what define us. So, too, for the life and times of Commander Shepard."