Here are the following tips:
1.When you are running the software you can set some options in the Settings menu by hitting the triangle button. Make sure Screensaver is selected to conserve energy and TV life
2.Exit the application and go back to the Xross Media Bar. Hit the triangle button when the Folding@home icon is selected. Choose Auto-Start from the right-hand menu and then choose idle time detection. For example, I choose 10 minutes. Now if you are not using the console for 10 straight minutes, Folding@home will run automatically so you don't have to think about it anymore. You can even turn your TV off and you don't have to be connected to network all the time. Folding@home will only access your network about 2-3 times a day.
3.To make sure Folding@home runs automatically, all you have to remember is after playing your favorite holiday game is to quit the game but leave the console powered on. Folding will not happen if you turn the console off.