Prototype 2's hero, James Heller, is pissed. From the game's very beginning cutscene he's already pissed. Who could blame him? He's at work but really hates his job, is dealing with a serious case of post-traumatic stress disorder and is stuck in a disease-ridden New York City (now called New York Zero.) Oh, and his whole family died as a result of the disease outbreak. But wait, it gets worse!