Quick history lesson for those who don't know: there's a character in Final Fight who in Japan was a sexy lady. A sexy lady you had to punch in the face. Her name was Poison.
Fearing this may not go down well overseas, in the West she was turned into a he. It was the same sexy character model, appearing entirely female, but had suddenly been labelled by the developer as a male. Making her one of video gaming's first, and to this day most notorious, transgender characters.
Poison remains a topic of debate not because he/she is transgender, but because apparently Capcom has never officially made the character's gender a matter of canon.