Leigh Alexander writes: Irrational's Ken Levine and his teams take an exploratory approach to developing the characters in their games that has more in common with theatrical practice than with traditional game development -- it's all about a focus on empathy and motivation. "Don't conceive of villainy," Levine suggests, on making memorable, nuanced antagonists. "You have to think about who is this guy, and what does he want?"
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Not to mention the designs were phenomenal in Bioshock and needless to say System Shock as well.