CBM: Hands-Down this has to be one of my favorite game series so far. Uncharted 2 was especially great and the whole thing is very cinematic and epic, so it shouldn't be too hard to translate with the right people involved. News of David O. Russel leaving was great since he's a good director, but not for Uncharted, and he was gonna massacre it with his film, adding Robert De Niro and Joe Pesci to be Mark Wahlberg's family that tags along on his adventures. That's just crazy, or as Charles Barkley would put it, trouble. Just make it Nate, Sully and Elena like the game, epic action-packed scenes and simple and straight-forward stuff like how Indy did it, except now its modern, and with even more spectacular sequences.
I kept none of the actual voice actors because I'm being realistic here and simply think they won't even be considered, though Elena, and Zoran's actors could easily do it, more-so than the others.