Call Of Juarez has moved on from it’s traditional western setting and has adapted to bring the McCall family into the 21st century. This McCall is a cop who must work with FBI agent Kimberley Evans and DEA agent Eddie Guerra to complete missions, crack the overall bombing and drugs case surrounding the Mendoza family and save the day. The Mendoza Cartel bombed the DEA offices killing DEA Agent Patrick Stone, who served with McCall in Vietnam. McCall and nemesis Juan Mendoza are the descendants of the protagonists and antagonist respectively of the previous Call Of Juarez games. This is another game in the COJ universe, just further along the timeline.