GameFocus writes: "Since we last saw them, the Saints have catapulted into international celebrities with their own brand name (energy drinks, merchandise, etc.) and flocks of adoring fans. This time, they’ve jumped ship, leaving Stilwater for the lovely Steelport. There are still multiple gangs the Saints will take on, but the major opposing force is The Syndicate (whom is still in full control of Stilwater as well) that wants to further their dominance across the world. It’s like Biggie said “Mo Money, Mo Problems”, so despite their success, the Third Street Saints will still have to lay down the law."