In Sanctum of Slime, players assume the role of a new recruit Ghostbuster. There's nobody familiar in the cast, it's a bunch of new characters. If this game were heavy on story, Destructoid would probably complain about this bunch of no-name cadets, but since it's not, it works. The story aspect of this game consists of comic book panels between levels and a few bits of written dialogue on screen. There are ghosts messing up New York City, and some supernatural jackass named Dumazu The Destroyer is responsible.