The place is the Sprawl, a long-established mining colony built on the Rings of Saturn that's now become a bustling metropolis and popular spaceport. The time is three years after the events of Dead Space, when the USG Ishimura succumbed to a devastating necromorph attack and became a floating tomb for thousands of humans. And the man, despite the futuristic facelift, is still very much Isaac Clarke. Three years of soul-searching have given him an attitude (not to mention a voice) and a thirst for taking down necromorphs. Which is pretty handy, really, because the bite-happy buggers are back in an invasion so large it threatens to wipe out the Sprawl in days.