The story of Resonance of Fate plays in a distant future. Humanity didn't listen to the all the ecologists and polluted Earth in such a way that it became completely inhabitable. Therefore construction of the floating city of Basel was started. Throughout time, waiting for Earth to be cleaned up, true cities were formed in the mechanical tower and everything started leading its own life. The machines created to fight pollution were forgotten and and slowly also the tower started to wither. This is seen in the gruesome mutations in the lower classes of the population, living in the lower levels.