If you've never heard of Resident Evil 4 before then you've been living under a rock. There's simply no need to bother you with the obligatory introduction, as this is a game that needs no introduction: it simply rocks. Whether or not you've played Resident Evil 4 before doesn't matter. The bottom line is this.
If you loved the game on either the GameCube or PlayStation 2, then you'll love it even more on Wii. And if you've never played it before, then you'll finally understand why the rest of the world is so in love with Capcom's horror-adventure.