Diehard GameFAN writes: "I enjoy a nice tower defense game every once in a while, but with access to the Internet, at the same time, it's kind of spoiled me in regard to the genre. When you jump on the Internet, you can find a massive number of free tower defense games just waiting for someone to give them a tender click of the mouse. So whenever a tower defense game would land on a console or handheld, a price of $20 or more would usually equate to sticker shock. Fortunately, Hudson Entertainment looked to do something a little different with the genre by mixing the tower defense genre with a card management scheme and for the first time, I paid attention to a handheld tower defense game. By tossing in a fantasy element akin to what people might see in Magic: The Gathering, Creature Defense creates a unique identity for itself, but fans of tower defense games will be pleased to know the title didn't mess around with what makes the genre fun."