Gregory House is the kind of doctor that you love to hate. His arrogance and sarcasm is trumped only by his knowledge of medicine, and the Fox drama has been a hit because there really hasn't been anything so perversely enjoyable as watching a genius doctor with the bedside manner of a weasel.
Whether or not you are familiar with the show, you could probably conjure up some fun and creative ways to turn such a show into a game. It is unlikely, however, that you'd come up with anything as bizarre as what Hands-On Mobile has cooked up. Not only does it take a while to figure what the heck is going on in the game, but by the time you've gotten it, you're already seen everything it has to offer.