Batman: Arkham Asylum 2 could not be set in Arkham at all, if comments made by the game's senior gameplay programmer, Paul Denning should be taken seriously.
Speaking in a retrospective on the original game in PC Zone magazine, Denning said the Gotham prison had probably "run its course" and other areas in the city would be "ideal" for gameplay.
"I think you're probably right in that it's almost run its course," he replied, when asked if there were other areas of Gotham developer Rocksteady would like to explore.
"We did pick a selection of buildings that we thought would fit the [original] game well," he added. "You could quite easily point out that there are various things that you wouldn't usually find in an asylum especially on an island that's supposedly self-contained.