Here's an interview with Richard Diamant, the Lead Character Artist of Uncharted: Drake's Fortune at Naughty Dog. He has also provided some models of the two leads from the game.
"3DTotal : What is your main role at naughty dog?
Rich : I was initially hired as a character artist but was quickly promoted to Lead Character Artist, in charge of overseeing anything character related. I deal mostly with character pipelines and coming up with both new and innovative ideas. I also get the honor of working on all of the main characters in the game.
3DTotal : How does it compare to previous jobs you have had?
Rich : Naughty Dog is on the forefront of technology which allows me to be on the forefront of next generation character development. I've never actually been at a place that is all about setting new standards and has the means of doing so. Naughty Dog also has an amazing relationship with Sony, which allows us almost complete control of how our game turns out. The freedom we have to explore and innovate is truly amazing."