"I am betting that the main difference will be mostly related to disc swapping. The biggest clue was when Kitase made it a point to indicate that the PS3 version of the game won't be hampered by disc swapping issues due to the Blu-ray player. Since the mediocre Blue Dragon game used three DVD discs it does make one wonder how many discs Final Fantasy XIII will be on.
The game will hit Japan exclusively on the PS3 this year. Gamers overseas will have to wait to get their hands on this title April of next year courtesy of Microsoft and Square Enix. However, one thing is for sure, regardless of which platform you get it on the game will be awesome."