In late 2006, Take-Two Interactive spent tens of millions to acquire Firaxis, developer of the Civilization series of strategy games. Given the publisher's investment and the franchise's massive popularity, it was only a matter of time until a new installment was announced.
As it turns out, the time in question was this week. Buried in yesterday's Take-Two earnings report was news that yes, a new Civilization game is planned. The report did not specify whether or not said game would be the inevitable Civilization V or a spin-off like CivCity: Rome. The prospects of a console or portable Civilization title have also been rumored.