Resident Evil 5 didn't really stand out in terms of any core changes. It had great graphics, decent music and some slightly cheesy voice acting, but hey, it wouldn't be an RE game without the latter. It's part of the charm. You still are running around, shooting zombies and monsters and collecting items. One of the things that was interesting is that enemies randomly dissolve into items ranging from grenades to herbs, which can quite dramatically change the difficulty of the game based on what you get and when.