Rise of the Argonauts takes players through an adventure inspired by Jason and the Golden Fleece, a tale from Greek and Roman mythology. In this game, the princess Alceme is assassinated during the wedding ceremony to Jason, king of Iolcus. Jason, distraught with the injustice of her death, decides to seek out a way to bring her back to life, which ultimately puts him on the path to the Golden Fleece. Four gods (Ares, Apollo, Hermes and Athena) take an interest in Jason's quest and aid him with special weapons and abilities. Additionally, Jason will fight alongside his crew, the Argonauts, comprised of famous heroes like Hercules, Atalanta and Achilles. Together, the heroes embark on a journey that goes deeper than just returning a bride from the dead.