The player is inserted into the story as a new rookie Ghostbuster. On the PS3, Xbox 360, and PC versions, the game's associate producer Ryan French is the model for the character – a Caucasian male with short, shaved brown hair with the name "Rookie" on his name tag.
The events of the game occur during Thanksgiving 1991, two years after the events in Ghostbusters II. Players portray a new recruit hired to test Egon Spengler and Ray Stantz's new equipment, during a recent rise of paranormal activity. Along the way, you battle ghosts from the films, such as Vigo, Slimer, Gozer, and Stay Puft Marshmallow Man.