Siliconera: "Hana Yori Dango -Koi Seyo Onago- is clearly a game designed with the fans in mind. Its as though the whole Hana Yori Dango storyline established in the manga, anime, movie and tv dramas has been rewritten to allow the player to experience it all as the main character.
The game starts from the very beginning of the Hana Yori Dango series. Tsukushi is still there, but she's more of a minor character and you're in her place as the star. So you'll be the one getting the red tag from the F4 (and thus temporarily become a target of school-wide harassment), you'll be the one who befriends Shizuka and sees her and Rui off, you'll be the one Sakurako picks on and tries to turn everyone against, and so on."