For the most part, the losing conditions in games follow a pretty standard format. You lose all your health or lives, or the time runs out, or a plot-central character dies – and then the controller breaks because it’s been thrown savagely against a wall.
Something about a game over screen conjures up loads of negative emotions. There’s frustration, if you’ve just lost a particularly close fight; despair, if it’s been a million years since the last save point; or even pure anger, when the AI is blatantly cheating you out of your rightful victory. It’s even worse if it happens very suddenly – all that steady progress gone in the blink of an eye.