X-Play had a chance to play Resistance 2 multiplayer for about an hour at E3 2008 and it's looking good. They believe they were playing against bots, but if they were human opponents, X-Play wrecked them. This, unfortunately, does not speak highly for the game's bot AI or Insomniac's play testers.
On the plus side, the game is incredibly fun. Insomniac has refined the core gameplay of Resistance multiplayer with weapon loadouts that create 'soft' classes. At the start of a round and between respawns you can select from different primary weapons and a single 'power' or 'perk'.