Serena Nelson writes: "To bring us up to speed, what happens in Gender Bender DNA Twister Extreme is that a couple scientists working at a pharmaceuticals company secretly worked on a formula to turn themselves into women. This backfires in the most spectacular way, irreversibly turning everyone in the building into the opposite sex. Including Nathan, one of the big wigs of the company. I'm only stating this here because Nadine's path leads directly into Rose/Russell's. Both of whom get married at the end."