"The Binding of Isaac is a game about child abuse, both mythological and semi-autobiographical. While its numerous opaque endings are open to interpretation, there is no way to shy away from its distressing foundational theme. It's alluded to in the game's title, borrowed from the myth that features in all three major monotheistic religions in which Abraham comes close to sacrificing his bewildered child, Isaac. And it's made explicit in the game's introductory sequence, which depicts a young boy being chased by his zealot mother, who has been driven to fanaticism by a diet of religious TV and now wants to cleanse her son of his sin with the aid of a carving knife. The eponymous Isaac flees his parent and retreats into the basement beneath the family's house, where responsibility for his safety passes to us."