Voters also have a chance to win Wii and Xbox 360 consoles, as well as Sony TVs, videogames, magazine subscriptions and accessories.
Last year's winners included Gears of War, LOTR: Shadows of Angmar and God of War II. Over 750,000 votes were cast.
Possible winners of "Ultimate Game of the Year" this year include Age of Conan, Assassin's Creed, BioShock, Burnout Paradise, Call of Duty 4, Enemy Territory: Quake Wars, Grand Theft Auto IV, Halo 3, Mario Kart Wii, Mass Effect, Metal Gear Solid 4, Portal, Super Mario Galaxy, Super Smash Bros. Brawl and The Witcher.
The Golden Joysticks are run by Next-Gen publisher Future.