There have been a lot of interesting new takes on the Roguelike genre lately. FTL put you in command of an enterprise-esque starship. Eldritch combined Bioshock-style combat with Minecraft's voxel-based randomness. The upcoming Crypt of the Necrodancer adds an extra D (for dungeon-crawling) to DDR. Billing itself as a "reverse-roguelike," Guild of Dungeoneering (which is currently up on Steam Greenlight) has similar ambitions. Unfortunately, whether or not in can achieve them remains to be seen.