As with Scene It?, there's no single-player mode to speak of (unless you enjoy playing against some A.I. tools). But there's also no reason to miss it: Wits & Wagers lets up to six players connect over Live from any combo of 360s and couches (for example, three players from one house and 360, two from another, one from a third), or four players can gather around a single console.
This flexibility allows Wits & Wagers to do exactly what a good party game should - let you laugh your ass off and have fun with your friends. Good job, XBLA - more like this, please.