In the new Uncharted teaser trailer released by Naughty Dog, the teaser shows shows a map of the "Cape of Good Hope" which has its own history of pirating.
In the url provided you see images of what appear to be characters concepts at Naughty Dog, these concepts look like olden day pirates in the 17th century.
A Pirate Round was a sailing route followed by certain English pirates, mainly during the late 17th century. The course led from the western Atlantic, around the southern tip of Africa(Cape of Good Hope)stopping at Madagascar.
Just before the Uncharted Logo appears in the teaser trailer, the country of Madagascar is marked with an "X", It is traditionally used on maps to indicate locations, most famously on treasure maps.