LocoCycle features a talking, battling motorcycle named Iris that drags a mechanic behind her by the pant leg. Iris' nemesis is a mean, gruff-talking motorbike that takes a moment to somehow munch on a giant hamburger in a roadside diner. Iris throws around Pablo, the mechanic, as if he's a battle-ready boomerang, all in the name of attending a festival she saw advertised in a biker magazine. Iris' Mecca is Scottsburg, Indiana. It's there where she belongs.