Pandora's Reflection is a strategy game in real time with some elements of turn-based strategy. Its stage Hades, an inhospitable place, where the poor are oppressed and a gray rain falls from the sky and malignant slowly weakens living beings throughout their existence, culminating in his death. People live in fear of both the gray rain as corrupt men, the rich of the world, a bit like our world with the addition of a rain.
The story revolves around a young alchemist named Claude and his sister Yuri. Yuri was inflicted with a curse that inflicts constant pain. Claude uses his powers of alchemy to create medicines for her, and the two travel the land in search of an ingredient quite coveted, snowdrops.